Osteogenic differences in cultured rat periosteal cells under hypoxic and normal conditions
نویسندگان
چکیده
منابع مشابه
Platelet releasate increases the proliferation and migration of bone marrow-derived cells cultured under osteogenic conditions.
Concentrated platelets and their products are currently being used as a clinical tool to accelerate endosseous wound healing. However, there is little understanding regarding the actions of platelets and platelet-released products on osteogenic cells. We show, herein, that releasate from thrombin-activated platelets increases the migration and proliferation of osteogenic cultures of bone marrow...
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The fungus Aspergillus nidulans reduces nitrate to ammonium and simultaneously oxidizes ethanol to acetate to generate ATP under hypoxic conditions in a mechanism called ammonia fermentation (Takasaki, K. et al.. J. Biol. Chem. 2004, 279, 12414-12420). To elucidate the mechanism, the fungus was cultured under normoxic and hypoxic (ammonia fermenting) conditions, intracellular proteins were reso...
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Bone marrow derived human mesenchymal stem cells (hMSCs) have attracted great interest from both bench and clinical researchers because of their pluripotency and ease of expansion ex vivo. However, these cells do finally reach a senescent stage and lose their multipotent potential. Proliferation of these cells is limited up to the time of their senescence, which limits their supply, and they ma...
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INTRODUCTION The periosteum may have an important function of new bone formation because of the abundant blood supply and the presence of osteoprogenitor cells. Periosteal cells have also been used for bone and cartilage formation. Though there have been many studies about the osteogenesis using periosteum, and osteogenic activity of osteoprogenitor cells such as mesenchymal stem cells(MSCs), l...
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In hypoxia, mitochondrial respiration is decreased, thereby leading to a buildup of reducing equivalents that cannot be transferred to O2 at the cytochrome oxidase. This condition, called reductive stress, can paradoxically lead to enhanced formation of reactive O2 species, or a decrease in the ability of the cell to defend against an oxidative stress. We hypothesized that antioxidants would pr...
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ژورنال
عنوان ژورنال: Experimental and Therapeutic Medicine
سال: 2011
ISSN: 1792-0981,1792-1015
DOI: 10.3892/etm.2011.393